26S proteasome exhibits endoribonuclease activity controlled by extra-cellular stimuli
نویسندگان
چکیده
منابع مشابه
Parkin directly modulates 26S proteasome activity.
Parkinson's disease (PD) is a common neurodegenerative disease that involves the deterioration of dopaminergic neurons in the substantia nigra pars compacta. Although the etiology of PD remains poorly understood, recent genetic, postmortem, and experimental evidence shows that abnormal protein accumulation and subsequent aggregate formation are prominent features of both sporadic and familial P...
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Cellular processes such as transcription and DNA repair may be regulated through diverse mechanisms, including RNA synthesis, protein synthesis, posttranslational modification and protein degradation. The 26S proteasome, which is responsible for degrading a broad spectrum of proteins, has been shown to interact with several nucleotide excision repair proteins, including xeroderma pigmentosum B ...
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Pathognomonic accumulation of ubiquitin (Ub) conjugates in human neurodegenerative diseases, such as Huntington's disease, suggests that highly aggregated proteins interfere with 26S proteasome activity. In this paper, we examine possible mechanisms by which an N-terminal fragment of mutant huntingtin (htt; N-htt) inhibits 26S function. We show that ubiquitinated N-htt-whether aggregated or not...
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The epithelial-mesenchymal transition (EMT) endows carcinoma cells with phenotypic plasticity that can facilitate the formation of cancer stem cells (CSCs) and contribute to the metastatic cascade. While there is substantial support for the role of EMT in driving cancer cell dissemination, less is known about the intracellular molecular mechanisms that govern formation of CSCs via EMT. Here we ...
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Ji Won Um,1 Eunju Im,1 Hyun Jung Lee,1 Boram Min,1 Lang Yoo,1 Jiho Yoo,1 Hermann Lübbert,3 Christine Stichel-Gunkel,4 Hyun-Soo Cho,1 Jong Bok Yoon,2 and Kwang Chul Chung1 Departments of 1Biology and 2Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea, 3Department of Animal Physiology, Ruhr-University Bochum, D-44780 Bochum, Germany, and 4Biofrontera...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2010
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.9.4.10829